Meaning

1. pumpkin, gourd, squash (any plant of the genus Cucurbita)
2. pumpkin, gourd, squash (fruit of this plant)
3. (colloquial,slang) head, noggin (part of the body of an animal or human which contains the brain, mouth and main sense organs)
4. fatso, butterball (overweight person)
5. F (failing grade, with the next best grade being either a D or an E)
6. (slang) fist (hand with the fingers clenched or curled inward)