fuck you, fuck off, go fuck yourself; get lost, up yours; shove it up your ass.
Frequency
Hyphenated as
vaf‧fan‧cù‧lo
Pronounced as (IPA)
/vaf.fanˈku.lo/
Etymology
Contraction of va' a fa' 'n culo, where fa' and 'n are contractions of fare and in, respectively. Literally, “go do [it] in [the] ass”.
Compare French va te faire enculer, Sicilian vâ fa' 'n culu (or vattilla a fari nculari), Spanish vete a tomar por culo, Portuguese vai tomar no cu.