Significat

1. To perform a work or labour; to exert power or strength, physical or mechanical; to act.
2. To produce an effect.
3. To produce an effect.
4. To produce an effect.
5. To bring about as an effect; to cause.
6. To perform some manual act upon a human body in a methodical manner, and usually with instruments, with a view to restore soundness or health, as in amputation, lithotomy, etc.
7. To deal in stocks or any commodity with a view to speculative profits.
8. To put into, or to continue in, operation or activity; to work.